Protein Details: Volume-regulated anion channel subunit LRRC8C

Function

Non-essential component of the volume-regulated anion channel (VRAC; also named VSOAC channel); an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids; such as aspartate and glutamate; in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2-3-cGAMP); an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B; LRRC8C; LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

Sequence

PDB Structures

Ligand Binding